Challenging targets
Measuring accurate kinetics of compounds on membrane proteins embedded within their native environment (GPCRs, Ion Channels, other receptor classes e.g. ACE)
Intrinsically Discorded Proteins (IDP)
Challenging modalities
Fragment screening, covalent fragments, also small molecules, peptides, antibodies, oligonucleotide therapeutics
Detect small or large molecules as biosensing is independent of the molecular weight
We can detect artifacts caused by aggregation and non-specific binding of fragments
Protein-Protein Interactions
PPI inhibitors, Induced proximity platforms (PROTAC)
The method is well positioned for screening Protein-Protein Interactions because it works on a 3-body binding problem