Membrane Proteins

Membrane proteins represent the majority of drug targets and are the most challenging class of proteins to study. Our technology is developed to accelerate drug development and reduce the complexity that makes membrane proteins so difficult today.

The problem

Membrane proteins represent the majority of drug targets however, they are notoriously difficult to work with. Many methods require that the proteins are at least temporarily removed from their native membranes which can detrimentally affect their structure, the way that they function and their ligand binding profile. This in turn can give misleading results in the drug discovery process resulting in wasted time and money.

How we solve the problem

With InSingulo, you can measure your membrane protein embedded within the native membrane. There is no need for a membrane-free system or a synthetic membrane which are common alternatives. When screening for drug targets, it is best to use a platform that is as close to the natural environment as possible. With membrane proteins, it doesn’t get closer than being embedded in the native cell membrane.

InSingulo’s dISA technology works perfectly with other membrane systems such as reconstituted proteoliposomes, virus-like particles (VLPs) lipid nanodiscs, proteoliposomes from cell free expression, and many more.

With InSingulo’s dISA technology, membrane proteins are kept in the only environment that
can give you real confidence in your results: the native cell membrane.

InSingulo’s dISA technology allows keeping membrane proteins throughout the whole experimental workflow in the right lipid-based environment: the native cell membrane.

Illustrating the solution

What we can offer you